House of Blues Las Vegas is a music venue located in Mandalay Bay in the Las Vegas valley. The music venue was opened in 1999 with funds given by Aerosmith, River Phoenix, Paul Schaffer, Harvard University, James Belushi, and Dan Aykroyd. The venue accommodates approximately 2,000 people.

House of Blues also offers two Gospel Brunch showings every Sunday that features Southern Food with gospel music performed by local talent. It also hosts cocktail events such as Nibbles and Sips and Bubbles for Beauties in the Foundation Room.