The Old Crow Medicine Show hails from Nashville, TN, and they play Americana string music. Since 1998, they have been creating music. September 17, 2013, was the day they joined the Grand Ole Opry. Their 8th studio album, 2014's Remedy, won a Grammy for Best Folk Album.

Folk, alternative country, and old-time elements come together in their music. The band performs original songs and a diverse range of blues and folk music from the era before World War II.

On April 20, 2018, the band celebrated their 20th anniversary as a unit with the release of Volunteer, their sixth studio album via Columbia Nashville. This marked a significant milestone in their career, as they made their Columbia Nashville debut with the April 28, 2017, release of 50 Years of Blonde on Blonde, demonstrating their growth and evolution.

April 22, 2022, was the release date of the band's seventh studio album, Paint This Town. Since the second departure of founding member Fuqua at the end of 2019, this is their first with members Jerry Pentecost (drums/percussion), Mike Harris (banjo/guitar), and Mason Via (guitar/vocals).

Old Crow Medicine Show's international appeal was showcased at the biggest country music festival in Europe, C2C: Country to Country, which took place in March 2023. The band performed at three different venues: Dublin's 3Arena, Glasgow's OVO Hydro, and London's The O2 Arena, demonstrating the scale of their fan base and their ability to captivate audiences worldwide.

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